Institutions / Siren, L.L.C. / Holdings
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Siren, L.L.C.

All holdings · as of Dec 31, 2025

113 positions

CompanyClassValueShares% of portfolio
Scholar Rock Holding Corp—$476.84M10,825,01314.2%
Kymera Therapeutics, Inc.—$255.75M3,286,8307.6%
BeOne Medicines Ltd.ONCADR$151.91M500,0004.5%
Edgewise Therapeutics, Inc.—$112.41M4,529,9903.4%
Revolution Medicines, Inc.—$106.34M1,335,0753.2%
Centessa Pharmaceuticals PLC—$100.73M4,027,5173.0%
ARROWHEAD PHARMACEUTICALS, INC.—$99.62M1,500,4763.0%
Bicara Therapeutics Inc.—$87.80M5,216,9692.6%
Olema Pharmaceuticals, Inc.—$82.52M3,300,7002.5%
Disc Medicine, Inc.IRONCommon Stock$78.49M988,4012.3%
Structure Therapeutics Inc.GPCRADR$75.02M1,078,6982.2%
Tango Therapeutics, Inc.—$72.35M8,165,3742.2%
Arcus Biosciences, Inc.—$71.66M3,007,0772.1%
Stoke Therapeutics, Inc.—$71.33M2,247,3472.1%
Crinetics Pharmaceuticals, Inc.—$70.18M1,507,6362.1%
Dyne Therapeutics, Inc.—$68.52M3,502,9412.0%
Apellis Pharmaceuticals, Inc.—$64.77M2,578,3961.9%
Cogent Biosciences, Inc.—$57.87M1,629,2791.7%
Septerna, Inc.SEPNCommon Stock$55.76M2,000,0001.7%
Taysha Gene Therapies, Inc.TSHACommon Stock$55.71M10,129,9131.7%
RHYTHM PHARMACEUTICALS, INC.—$53.52M499,9751.6%
ASCENDIS PHARMA A/S—$50.30M235,8621.5%
RAPT Therapeutics Inc—$46.57M1,375,0001.4%
Taboola.com Ltd—$45.96M9,969,4951.4%
LEXICON PHARMACEUTICALS, INC.LXRXCommon Stock$44.76M38,918,9031.3%
ZYMEWORKS INC.—$44.24M1,680,1211.3%
Solid Biosciences Inc.SLDBCommon Stock$43.37M7,690,4051.3%
WAVE Life Sciences Ltd—$41.65M2,450,0001.2%
Xenon Pharmaceuticals Inc.—$36.43M812,7611.1%
DBV TECHNOLOGIES S.A.DBVTADR$35.61M1,857,3621.1%
Erasca, Inc.ERASCommon Stock$32.58M8,757,2491.0%
enGene Therapeutics Inc.—$30.13M3,336,2640.9%
Trevi Therapeutics, Inc.—$28.63M2,286,8670.9%
SPYRE THERAPEUTICS, INC.—$26.82M818,5980.8%
MINERALYS THERAPEUTICS INCMLYSCommon Stock$25.40M699,9990.8%
Denali Therapeutics Inc.—$23.06M1,396,5130.7%
Remitly Global, Inc.—$22.33M1,618,2710.7%
Fulcrum Therapeutics, Inc.—$22.05M1,950,0000.7%
Rapport Therapeutics, Inc.RAPPCommon Stock$21.49M708,4690.6%
Silence Therapeutics plcSLNADR$17.70M2,911,4380.5%
IHS Holding Limited—$17.59M2,357,5200.5%
Gossamer Bio, Inc.—$16.15M5,208,9680.5%
Upstream Bio, Inc.UPBCommon Stock$15.98M588,4500.5%
Bicycle Therapeutics plcBCYCADR$14.25M2,012,7520.4%
Monopar Therapeutics Inc.MNPRCommon Stock$13.86M212,2980.4%
Cullinan Therapeutics, Inc.—$12.35M1,193,4100.4%
Sionna Therapeutics, Inc.—$12.34M300,0000.4%
Inhibikase Therapeutics, Inc.—$11.99M5,850,0000.4%
NovaBridge BiosciencesNBPADR$11.94M3,000,0000.4%
Amazon.com Inc—$11.89M51,5000.4%
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