Companies / Upstream Bio, Inc.

Upstream Bio, Inc.

Nasdaq: UPBCIK 2022626WALTHAM, MA

Financials · FY2025

Revenue$2.85M
Net income$-143.44M
Total debt—
Cash$79.40M
Diluted EPS$-2.66
Shares outstanding54.8M

Ownership

54.8M shares outstanding · as of Aug 4, 2026
0.32%Insiders
Ownership
Insiders0.32%175,215
Institutions96.30%52,742,183
Public float3.38%1,853,643

% of common shares outstanding (exact, from the latest cover-page filing). Institutions are quarterly 13F snapshots; insiders reflect current officers & directors.

Insiders 6

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Insider% of sharesShares
Sutherland Everett RandCEOChief Executive Officer · Director
0.13%72,907
Deykin AaronChief Medical Officer
0.06%32,687
Gray MichaelCFO and COO
0.05%28,795
Houghton AdamChief Business Officer
0.04%24,301
Ambrose AllisonGeneral Counsel
0.03%16,525
Renaud Ronald C JRDirector
——

Institutional holders 142

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HolderValue% of shares
Fmr LLC$204.12M13.73%
Decheng Capital LLC$85.33M5.74%
Norges Bank$78.26M5.26%
Enavate Sciences GP, LLC$66.78M4.49%
Vanguard Group Inc$64.85M4.36%
Orbimed Advisors LLC$51.24M10.40%
UBS Group AG$49.04M3.30%
Janus Henderson Group PLC$41.42M2.79%
Bain Capital Life Sciences Investors, LLC$36.10M2.43%
Omega Fund Management, LLC$36.01M2.42%

Activity

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InsidersInstitutions
What insiders are doing in this stock (Form 4).
DateActorActionSecurityValueShares ΔPosition afterImpact
Mar 16, 2026Sutherland Everett Rand
CEO
SellCommon Stock$19.4K-2K
-2.79%
72,907
0.13% of shares
low
Mar 16, 2026Deykin Aaron
Executive
SellCommon Stock$8.3K-894
-2.66%
32,687
0.06% of shares
low
Mar 16, 2026Gray Michael
Executive
SellCommon Stock$7.9K-852
-2.79%
29,648
0.05% of shares
low
Mar 16, 2026Houghton Adam
Executive
SellCommon Stock$6.5K-699
-2.80%
24,301
0.04% of shares
low
Jun 16, 2026Gray Michael
Executive
SellCommon Stock$5.2K-853
-2.88%
28,795
0.05% of shares
low
Mar 16, 2026Ambrose Allison
Executive
SellCommon Stock$4.4K-475
-2.79%
16,525
0.03% of shares
low
Jan 2, 2026Deykin Aaron
Executive
GrantCommon Stock$0+32K
+2024.04%
33,581
0.06% of shares
low
Jan 2, 2026Ambrose Allison
Executive
GrantCommon Stock$0+17K
17,000
0.03% of shares
low

Securities

via CUSIP / OpenFIGI
SymbolTypeMarketCUSIPFIGI
UPBCommon StockEquity91678A107BBG017Y2X923