Companies / Upstream Bio, Inc.
Upstream Bio, Inc.
Nasdaq: UPBCIK 2022626WALTHAM, MA
Financials · FY2025
Ownership
54.8M shares outstanding · as of Aug 4, 2026
Ownership
| Insiders | 0.32% | 175,215 |
| Institutions | 96.30% | 52,742,183 |
| Public float | 3.38% | 1,853,643 |
% of common shares outstanding (exact, from the latest cover-page filing). Institutions are quarterly 13F snapshots; insiders reflect current officers & directors.
Insiders 6
View all →| Insider | % of shares | Shares |
|---|---|---|
Sutherland Everett RandCEOChief Executive Officer · Director | 0.13% | 72,907 |
Deykin AaronChief Medical Officer | 0.06% | 32,687 |
Gray MichaelCFO and COO | 0.05% | 28,795 |
Houghton AdamChief Business Officer | 0.04% | 24,301 |
Ambrose AllisonGeneral Counsel | 0.03% | 16,525 |
Renaud Ronald C JRDirector | — | — |
Institutional holders 142
View all →| Holder | Value | % of shares |
|---|---|---|
| $204.12M | 13.73% | |
| $85.33M | 5.74% | |
| $78.26M | 5.26% | |
| $66.78M | 4.49% | |
| $64.85M | 4.36% | |
| $51.24M | 10.40% | |
| $49.04M | 3.30% | |
| $41.42M | 2.79% | |
| $36.10M | 2.43% | |
| $36.01M | 2.42% |
Activity
Jun 30, 2026View all →
InsidersInstitutions
Who's accumulating and trimming this stock (13F).| Date | Actor | Action | Security | Value | Shares Δ | Position after | Impact |
|---|---|---|---|---|---|---|---|
| Q1 2026 as of | Norges Bank 13F manager | Exit | Common Stock | $-78.26M | -2.9M -100.00% | — | high |
| Q4 2025 as of | Norges Bank 13F manager | Add | Common Stock | $51.93M | +1.9M +197.21% | 2,882,647 5.26% of shares | high |
| Q1 2026 as of | Janus Henderson Group PLC 13F manager | Exit | Common Stock | $-41.42M | -1.5M -100.00% | — | medium |
| Q4 2025 as of | Barclays PLC 13F manager | Add | Common Stock | $11.92M | +439K +514.78% | 524,499 0.96% of shares | medium |
| Q1 2026 as of | Federated Hermes Inc 13F manager | Add | Common Stock | $8.81M | +979K +203169.29% | 979,758 1.79% of shares | medium |
| Q1 2026 as of | Altshuler Shaham Ltd 13F manager | Trim | Common Stock | $-8.65M | -961K -71.67% | 380,061 0.69% of shares | medium |
| Q1 2026 as of | Great Point Partners, LLC 13F manager | Exit | Common Stock | $-8.14M | -300K -100.00% | — | medium |
| Q1 2026 as of | D. E. Shaw & Co., Inc. 13F manager | Add | Common Stock | $7.14M | +793K +2928.61% | 820,480 1.50% of shares | medium |
Securities
via CUSIP / OpenFIGI
| Symbol | Type | CUSIP |
|---|---|---|
| UPB | Common Stock | 91678A107 |