Companies / Spyre Therapeutics, Inc.

Spyre Therapeutics, Inc.

Nasdaq: SYRECIK 1636282WALTHAM, MAaegleabio.com

Financials · FY2025

Revenue$0
Net income$-155.20M
Total debt
Cash$162.01M
Diluted EPS$-49.12
Shares outstanding88.2M

Ownership

88.2M shares outstanding · as of Jul 28, 2026
1.0%Insiders
Ownership
Insiders1.03%909,140
10%+ / strategic2.15%1,892,200
Institutions93.23%82,208,345
Public float3.59%3,164,077

% of common shares outstanding (exact, from the latest cover-page filing). Institutions are quarterly 13F snapshots; insiders reflect current officers & directors.

Insiders 5

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Insider% of sharesShares
Turtle CameronCEOChief Executive Officer · Director
0.73%642,540
0.19%168,606
Burrows Scott LChief Financial Officer
0.11%97,994
King-Jones HeidySee Remarks
Sloan SheldonChief Medical Officer

Institutional holders 162

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HolderValue% of shares
BlackRock, Inc.$577.66M7.38%
Fmr LLC$381.29M13.20%
State Street Corporation$271.44M3.47%
Perceptive Advisors LLC$190.83M4.29%
RTW Investments, LP$136.67M4.73%
Vanguard Group Inc$132.19M4.58%
Fairmount Funds Management LLC$131.63M4.56%
Remedium Capital Partners, LLC$129.99M1.66%
VR Adviser, LLC$120.74M4.18%
Capital International Investors$114.42M3.96%

Activity

InsidersInstitutions
What insiders are doing in this stock (Form 4).
DateActorActionSecurityValueShares ΔPosition afterImpact
Feb 2, 2026Turtle Cameron
CEO
SellCommon Stock$461.6K-14K
-2.09%
657,540
0.75% of shares
medium
Jan 2, 2026Turtle Cameron
CEO
SellCommon Stock$387.2K-13K
-1.85%
674,198
0.76% of shares
medium
Mar 2, 2026Turtle Cameron
CEO
SellCommon Stock$386.7K-9K
-1.40%
642,540
0.73% of shares
medium
Mar 2, 2026Turtle Cameron
CEO
SellCommon Stock$246.2K-6K
-0.90%
651,640
0.74% of shares
medium
Mar 3, 2026Burrows Scott L
Executive
SellCommon Stock$93.3K-2K
-2.29%
98,194
0.11% of shares
low
Jan 2, 2026Turtle Cameron
CEO
SellCommon Stock$69.7K-2K
-0.33%
672,007
0.76% of shares
low
Mar 3, 2026Burrows Scott L
Executive
ExerciseCommon Stock$36.3K+3K
+2.55%
100,494
0.11% of shares
low
Feb 2, 2026Turtle Cameron
CEO
SellCommon Stock$30.5K-957
-0.14%
671,583
0.76% of shares
low

5%+ ownership events

Schedule 13D / 13G
FilerStance% of classSharesDate
Vanguard Group IncPassive13G/A0
Tang Capital Management, LLCPassive13G/A1,892,200
Perceptive Advisors LLCPassive13G

Securities

via CUSIP / OpenFIGI
SymbolTypeMarketCUSIPFIGI
SYRE00773J202