Companies / Spyre Therapeutics, Inc.
Spyre Therapeutics, Inc.
Financials · FY2025
Ownership
88.2M shares outstanding · as of Jul 28, 2026
Ownership
| Insiders | 1.03% | 909,140 |
| 10%+ / strategic | 2.15% | 1,892,200 |
| Institutions | 93.23% | 82,208,345 |
| Public float | 3.59% | 3,164,077 |
% of common shares outstanding (exact, from the latest cover-page filing). Institutions are quarterly 13F snapshots; insiders reflect current officers & directors.
Insiders 5
View all →| Insider | % of shares | Shares |
|---|---|---|
Turtle CameronCEOChief Executive Officer · Director | 0.73% | 642,540 |
Henderson Michael ThomasDirector | 0.19% | 168,606 |
Burrows Scott LChief Financial Officer | 0.11% | 97,994 |
King-Jones HeidySee Remarks | — | — |
Sloan SheldonChief Medical Officer | — | — |
Institutional holders 162
View all →| Holder | Value | % of shares |
|---|---|---|
| $577.66M | 7.38% | |
| $381.29M | 13.20% | |
| $271.44M | 3.47% | |
| $190.83M | 4.29% | |
| $136.67M | 4.73% | |
| $132.19M | 4.58% | |
| $131.63M | 4.56% | |
| $129.99M | 1.66% | |
| $120.74M | 4.18% | |
| $114.42M | 3.96% |
Activity
Jun 30, 2026View all →
InsidersInstitutions
Who's accumulating and trimming this stock (13F).| Date | Actor | Action | Security | Value | Shares Δ | Position after | Impact |
|---|---|---|---|---|---|---|---|
| Q2 2026 as of | BlackRock, Inc. 13F manager | Add | — | $87.40M | +985K +17.83% | 6,506,605 7.38% of shares | high |
| Q2 2026 as of | State Street Corporation 13F manager | Add | — | $70.54M | +795K +35.11% | 3,057,416 3.47% of shares | high |
| Q1 2026 as of | Perceptive Advisors LLC 13F manager | Add | — | $36.01M | +714K +23.26% | 3,783,225 4.29% of shares | medium |
| Q1 2026 as of | Deerfield Management Company, L.P. 13F manager | Exit | — | $-23.28M | -711K -100.00% | — | medium |
| Q2 2026 as of | Victory Capital Management, Inc. 13F manager | Add | — | $23.25M | +262K +89.64% | 553,980 0.63% of shares | medium |
| Q1 2026 as of | Blackstone Inc 13F manager | New | — | $14.77M | +293K | 292,847 0.33% of shares | medium |
| Q1 2026 as of | First Trust Advisors LP 13F manager | New | — | $9.00M | +178K | 178,389 0.20% of shares | medium |
| Q1 2026 as of | Janus Henderson Group PLC 13F manager | Trim | — | $-8.72M | -173K -9.45% | 1,656,164 1.88% of shares | medium |
5%+ ownership events
Schedule 13D / 13G
| Filer | Stance | % of class |
|---|---|---|
| Vanguard Group Inc | Passive13G/A | — |
| Tang Capital Management, LLC | Passive13G/A | — |
| Perceptive Advisors LLC | Passive13G | — |
Securities
via CUSIP / OpenFIGI
| Symbol | Type | CUSIP |
|---|---|---|
| SYRE | — | 00773J202 |