Companies / SPYRE THERAPEUTICS, INC. / Institutional holders

Spyre Therapeutics, Inc.

Institutional holders · 13F as of Jun 30, 2026

Holder	Value ↓	Shares	% of shares
BlackRock, Inc.	$577.66M	6,506,605	7.38%
FMR LLC	$381.29M	11,638,819	13.20%
STATE STREET CORPORATION	$271.44M	3,057,416	3.47%
Perceptive Advisors LLC	$190.83M	3,783,225	4.29%
RTW Investments, LP	$136.67M	4,171,996	4.73%
VANGUARD GROUP INC	$132.19M	4,035,074	4.58%
Fairmount Funds Management LLC	$131.63M	4,018,101	4.56%
Remedium Capital Partners, LLC	$129.99M	1,464,169	1.66%
VR Adviser, LLC	$120.74M	3,685,448	4.18%
Capital International Investors	$114.42M	3,492,541	3.96%
TANG CAPITAL MANAGEMENT, LLC	$95.44M	1,892,200	2.15%
DRIEHAUS CAPITAL MANAGEMENT LLC	$94.43M	2,882,420	3.27%
GEODE CAPITAL MANAGEMENT, LLC	$86.82M	1,720,912	1.95%
JANUS HENDERSON GROUP PLC	$83.59M	1,656,164	1.88%
RA Capital Management, L.P.	$81.79M	1,621,620	1.84%
Commodore Capital LP	$78.24M	2,388,245	2.71%
TCG Crossover Management, LLC	$62.26M	1,900,582	2.16%
BRAIDWELL LP	$53.55M	1,634,615	1.85%
Wellington Management Group LLP	$50.75M	1,549,284	1.76%
Baker Bros. Advisors LP	$50.44M	1,000,000	1.13%
Victory Capital Management, Inc.	$49.18M	553,980	0.63%
Paradigm BioCapital Advisors LP	$48.07M	1,467,266	1.66%
Affinity Asset Advisors, LLC	$46.93M	1,432,591	1.62%
Franklin Resources, Inc.	$36.34M	1,109,274	1.26%
EMERALD ADVISERS, LLC	$30.94M	613,365	0.70%
Pictet Asset Management Holding SA	$29.94M	913,960	1.04%
Siren, L.L.C.	$26.82M	818,598	0.93%
Polar Capital Holdings Plc	$24.25M	740,326	0.84%
DEERFIELD MANAGEMENT COMPANY, L.P.	$23.28M	710,626	0.81%
UBS Group AG	$22.30M	680,566	0.77%
Point72 Asset Management, L.P.	$21.70M	662,351	0.75%
EMERALD MUTUAL FUND ADVISERS TRUST	$20.59M	408,113	0.46%
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	$18.82M	574,622	0.65%
NORTHERN TRUST CORP	$18.38M	561,023	0.64%
DEUTSCHE BANK AG	$15.49M	174,459	0.20%
Blackstone Inc	$14.77M	292,847	0.33%
Candriam S.C.A.	$13.94M	425,534	0.48%
BANK OF AMERICA CORP /DE	$13.75M	419,727	0.48%
Bank of New York Mellon Corp/The	$9.65M	191,395	0.22%
THE GOLDMAN SACHS GROUP, INC.	$9.01M	275,065	0.31%
FIRST TRUST ADVISORS LP	$9.00M	178,389	0.20%
Woodline Partners LP	$8.71M	265,892	0.30%
Millennium Management LLC	$7.40M	146,639	0.17%
HighVista Strategies LLC	$7.38M	146,264	0.17%
MARSHALL WACE, LLP	$7.02M	139,259	0.16%
TD ASSET MANAGEMENT INC	$6.93M	137,390	0.16%
Capital World Investors	$6.56M	200,172	0.23%
Armistice Capital, LLC	$6.43M	196,426	0.22%
SilverArc Capital Management, LLC	$6.15M	187,737	0.21%
Morgan Stanley	$5.99M	182,734	0.21%