Institutions / Siren, L.L.C.

Siren, L.L.C.

CIK 2005245 · Institution · as of Dec 31, 2025
Portfolio value
$3.35B
Positions
113
As of
Dec 31, 2025

Top holdings

Dec 31, 2025View all 113 →
CompanyClassValueShares% of portfolio
Scholar Rock Holding Corp—$476.84M10,825,01314.2%
Kymera Therapeutics, Inc.—$255.75M3,286,8307.6%
BeOne Medicines Ltd.ONCADR$151.91M500,0004.5%
Edgewise Therapeutics, Inc.—$112.41M4,529,9903.4%
Revolution Medicines, Inc.—$106.34M1,335,0753.2%
Centessa Pharmaceuticals PLC—$100.73M4,027,5173.0%
Arrowhead Pharmaceuticals, Inc.—$99.62M1,500,4763.0%
Bicara Therapeutics Inc.—$87.80M5,216,9692.6%
Olema Pharmaceuticals, Inc.—$82.52M3,300,7002.5%
Disc Medicine, Inc.IRONCommon Stock$78.49M988,4012.3%
Structure Therapeutics Inc.GPCRADR$75.02M1,078,6982.2%
Tango Therapeutics, Inc.—$72.35M8,165,3742.2%
Arcus Biosciences, Inc.—$71.66M3,007,0772.1%
Stoke Therapeutics, Inc.—$71.33M2,247,3472.1%
Crinetics Pharmaceuticals, Inc.—$70.18M1,507,6362.1%
Dyne Therapeutics, Inc.—$68.52M3,502,9412.0%
Apellis Pharmaceuticals, Inc.—$64.77M2,578,3961.9%
Cogent Biosciences, Inc.—$57.87M1,629,2791.7%
Septerna, Inc.SEPNCommon Stock$55.76M2,000,0001.7%
Taysha Gene Therapies, Inc.TSHACommon Stock$55.71M10,129,9131.7%
Rhythm Pharmaceuticals, Inc.—$53.52M499,9751.6%
Ascendis Pharma A/S—$50.30M235,8621.5%
RAPT Therapeutics Inc—$46.57M1,375,0001.4%
Taboola.com Ltd—$45.96M9,969,4951.4%
Lexicon Pharmaceuticals, Inc.LXRXCommon Stock$44.76M38,918,9031.3%

Activity

Dec 31, 2025
InsidersInstitutions
This fund's 13F position changes — what it's buying and selling.
No quarter-over-quarter changes yet — position changes appear once we've ingested two consecutive 13F filings for this manager. We currently hold 1 quarter of holdings.