Institutions / Opaleye Management Inc. / Holdings

Opaleye Management Inc.

All holdings · as of Dec 31, 2025

Company	Class	Value ↓	Shares	% of portfolio
Harrow, Inc.	—	$191.34M	3,905,000	25.2%
Liquidia CorpLQDA	Common Stock	$84.98M	2,435,000	11.2%
Eton Pharmaceuticals, Inc.	—	$48.36M	2,860,000	6.4%
RHYTHM PHARMACEUTICALS, INC.	—	$35.32M	330,000	4.7%
Apogee Therapeutics, Inc.	—	$29.31M	388,257	3.9%
SANUWAVE Health Inc	—	$29.28M	981,267	3.9%
Stoke Therapeutics, Inc.	—	$22.06M	695,000	2.9%
Ocular Therapeutix, Inc	—	$19.36M	1,595,000	2.6%
Sol-Gel Technologies Ltd	—	$19.12M	453,739	2.5%
CG Oncology, Inc.	—	$17.02M	410,000	2.2%
TG Therapeutics Inc	—	$15.95M	535,000	2.1%
Disc Medicine, Inc.IRON	Common Stock	$15.88M	200,000	2.1%
Rezolute, Inc.	—	$14.84M	6,287,156	2.0%
CRESCENT BIOPHARMA, INC.	—	$13.97M	1,178,300	1.8%
Alkermes plc.	—	$13.71M	490,000	1.8%
Alpha Cognition Inc.	—	$13.46M	2,070,784	1.8%
Annexon, Inc.	—	$13.05M	2,600,000	1.7%
Edgewise Therapeutics, Inc.	—	$12.41M	500,000	1.6%
Codexis, Inc.	—	$11.07M	6,789,738	1.5%
PROTAGONIST THERAPEUTICS INC	—	$9.17M	105,000	1.2%
Gossamer Bio, Inc.	—	$8.43M	2,720,000	1.1%
MBX Biosciences, Inc.MBX	Common Stock	$8.20M	260,000	1.1%
Revolution Medicines, Inc.	—	$7.96M	100,000	1.1%
XOMA Royalty Corp	—	$7.78M	292,590	1.0%
Journey Medical CorpDERM	Common Stock	$7.52M	975,000	1.0%
Karyopharm Therapeutics Inc.	—	$6.84M	930,000	0.9%
JADE BIOSCIENCES, INC.	—	$6.60M	427,608	0.9%
UROGEN PHARMA LTD	—	$6.29M	268,423	0.8%
ALUMIS INC.ALMS	Common Stock	$5.22M	535,000	0.7%
Perspective Therapeutics, Inc.	—	$4.99M	1,184,500	0.7%
Voyager Therapeutics, Inc.	—	$4.70M	1,196,904	0.6%
Relmada Therapeutics, Inc.	—	$4.52M	935,000	0.6%
Tectonic Therapeutic, Inc.TECX	Common Stock	$4.48M	214,747	0.6%
Protalix BioTherapeutics, Inc.	—	$4.46M	2,478,176	0.6%
Trevi Therapeutics, Inc.	—	$4.32M	345,100	0.6%
Fortress Biotech, Inc.FBIO	Common Stock	$3.99M	1,090,000	0.5%
ROCKET PHARMACEUTICALS, INC.	—	$3.35M	955,000	0.4%
MEIRAGTX HOLDINGS PLC	—	$3.11M	390,844	0.4%
RIGEL PHARMACEUTICALS, INC.	—	$3.00M	70,000	0.4%
ZYMEWORKS INC.	—	$2.87M	108,929	0.4%
ASSERTIO HOLDINGS INC	—	$2.58M	285,000	0.3%
Ventyx Biosciences, Inc.	—	$2.27M	251,932	0.3%
Opus Genetics, Inc.	—	$2.25M	1,120,000	0.3%
Sutro Biopharma, Inc.	—	$2.21M	190,671	0.3%
Cabaletta Bio, Inc.	—	$1.97M	900,000	0.3%
Zentalis Pharmaceuticals, Inc.ZNTL	Common Stock	$1.89M	1,400,906	0.2%
GENERATION BIO CO	—	$1.76M	310,000	0.2%
BridgeBio Pharma, Inc.	—	$1.40M	18,319	0.2%
ENANTA PHARMACEUTICALS INC	—	$1.18M	75,000	0.2%
Q32 Bio Inc.	—	$708.4K	213,363	0.1%