Companies / Spyre Therapeutics, Inc. / Activity

Activity — Spyre Therapeutics, Inc.

64 moves.

Top impactInsider · CEO movesInsider · biggest buysInsider · biggest sellsInstitution · biggest movesInstitution · new positions
InsidersInstitutions
DateActorActionSecurityValueShares ΔPosition afterImpact
Q2 2026
as of
BlackRock, Inc.
13F manager
AddCommon stock$87.40M+985K
+17.83%
6,506,605
7.38% of shares
high
Q2 2026
as of
State Street Corporation
13F manager
AddCommon stock$70.54M+795K
+35.11%
3,057,416
3.47% of shares
high
Q1 2026
as of
Perceptive Advisors LLC
13F manager
AddCommon stock$36.01M+714K
+23.26%
3,783,225
4.29% of shares
medium
Q1 2026
as of
Deerfield Management Company, L.P.
13F manager
ExitCommon stock$-23.28M-711K
-100.00%
0
medium
Q2 2026
as of
Victory Capital Management, Inc.
13F manager
AddCommon stock$23.25M+262K
+89.64%
553,980
0.63% of shares
medium
Q1 2026
as of
Blackstone Inc
13F manager
NewCommon stock$14.77M+293K
292,847
0.33% of shares
medium
Q1 2026
as of
First Trust Advisors LP
13F manager
NewCommon stock$9.00M+178K
178,389
0.20% of shares
medium
Q1 2026
as of
Janus Henderson Group PLC
13F manager
TrimCommon stock$-8.72M-173K
-9.45%
1,656,164
1.88% of shares
medium
Q1 2026
as of
Victory Capital Management, Inc.
13F manager
AddCommon stock$7.37M+146K
+99.98%
292,126
0.33% of shares
medium
Q1 2026
as of
Marshall Wace, LLP
13F manager
NewCommon stock$7.02M+139K
139,259
0.16% of shares
medium
Q2 2026
as of
Deutsche Bank AG
13F manager
AddCommon stock$4.66M+53K
+43.07%
174,459
0.20% of shares
low
Q1 2026
as of
Millennium Management LLC
13F manager
AddCommon stock$3.55M+70K
+92.45%
146,639
0.17% of shares
low
Q1 2026
as of
Atle Fund Management AB
13F manager
NewCommon stock$3.49M+63K
62,735
0.07% of shares
low
Q1 2026
as of
Geode Capital Management, LLC
13F manager
AddCommon stock$3.12M+62K
+3.72%
1,720,912
1.95% of shares
low
Q1 2026
as of
Prudential Financial Inc
13F manager
NewCommon stock$3.00M+60K
59,555
0.07% of shares
low
Q4 2025
as of
Bank of America Corp /De
13F manager
AddCommon stock$2.45M+75K
+21.73%
419,727
0.48% of shares
low
Q1 2026
as of
HighVista Strategies LLC
13F manager
TrimCommon stock$-2.12M-42K
-22.29%
146,264
0.17% of shares
low
Q1 2025
as of
Barclays PLC
13F manager
AddCommon stock$1.48M+92K
+74.38%
214,606
0.24% of shares
low
Q1 2026
as of
Voya Investment Management LLC
13F manager
AddCommon stock$1.35M+27K
+97.86%
53,970
0.06% of shares
low
Q3 2024
as of
Barclays PLC
13F manager
AddCommon stock$1.22M+41K
+64.68%
105,467
0.12% of shares
low
Q1 2026
as of
Emerald Advisers, LLC
13F manager
TrimCommon stock$-1.15M-23K
-3.58%
613,365
0.70% of shares
low
Q4 2023
as of
Barclays PLC
13F manager
NewCommon stock$979.1K+45K
45,498
0.05% of shares
low
Q1 2026
as of
Balyasny Asset Management L.P.
13F manager
TrimCommon stock$-907.3K-18K
-24.49%
55,477
0.06% of shares
low
Q3 2025
as of
Barclays PLC
13F manager
TrimCommon stock$-809.8K-48K
-22.30%
168,330
0.19% of shares
low
Q2 2026
as of
Remedium Capital Partners, LLC
13F manager
AddCommon stock$704.7K+8K
+0.55%
1,464,169
1.66% of shares
low
Q1 2026
as of
TD Asset Management Inc
13F manager
TrimCommon stock$-627.1K-12K
-8.30%
137,390
0.16% of shares
low
Q1 2026
as of
Brown Advisory Inc
13F manager
NewCommon stock$625.5K+12K
12,400
0.01% of shares
low
Q2 2026
as of
Persistent Asset Partners Ltd
13F manager
AddCommon stock$578.3K+7K
+290.03%
8,760
<0.01% of shares
low
Q1 2026
as of
California State Teachers Retirement System
13F manager
AddCommon stock$565.1K+11K
+23.32%
59,242
0.07% of shares
low
Q4 2025
as of
Barclays PLC
13F manager
AddCommon stock$465.0K+14K
+8.43%
182,524
0.21% of shares
low
Q2 2024
as of
Barclays PLC
13F manager
AddCommon stock$425.1K+18K
+39.34%
64,043
0.07% of shares
low
Q4 2024
as of
Barclays PLC
13F manager
AddCommon stock$409.8K+18K
+16.69%
123,071
0.14% of shares
low
Q1 2026
as of
Los Angeles Capital Management LLC
13F manager
TrimCommon stock$-354.3K-7K
-54.53%
5,858
<0.01% of shares
low
Q1 2026
as of
BNP Paribas Financial Markets
13F manager
AddCommon stock$342.3K+7K
+57.29%
18,630
0.02% of shares
low
Q2 2026
as of
Carlyle Group Inc.
13F manager
ExitCommon stock$-315.1K-10K
-100.00%
0
low
Q1 2026
as of
Caxton Corp
13F manager
ExitCommon stock$-292.2K-9K
-100.00%
0
low
Q1 2026
as of
Profund Advisors LLC
13F manager
AddCommon stock$274.9K+5K
+26.47%
26,043
0.03% of shares
low
Q1 2026
as of
Principal Financial Group Inc
13F manager
NewCommon stock$216.8K+4K
4,299
<0.01% of shares
low
Q1 2026
as of
Emerald Mutual Fund Advisers Trust
13F manager
TrimCommon stock$-214.8K-4K
-1.03%
408,113
0.46% of shares
low
Q1 2026
as of
Rafferty Asset Management, LLC
13F manager
AddCommon stock$177.0K+4K
+6.57%
56,920
0.06% of shares
low
Q1 2026
as of
AQR Capital Management, LLC
13F manager
AddCommon stock$154.0K+3K
+17.14%
20,874
0.02% of shares
low
Q2 2026
as of
Arizona State Retirement System
13F manager
AddCommon stock$148.6K+2K
+12.13%
15,471
0.02% of shares
low
Q1 2026
as of
Zurcher Kantonalbank (Zurich Cantonalbank)
13F manager
AddCommon stock$140.8K+3K
+25.00%
13,955
0.02% of shares
low
Q1 2026
as of
ProShare Advisors LLC
13F manager
TrimCommon stock$-125.6K-2K
-15.58%
13,498
0.02% of shares
low
Q2 2026
as of
AlphaQuest LLC
13F manager
ExitCommon stock$-115.9K-4K
-100.00%
0
low
Q1 2026
as of
AllianceBernstein L.P.
13F manager
AddCommon stock$111.4K+3K
+5.04%
70,900
0.08% of shares
low
Q1 2026
as of
Rhumbline Advisers
13F manager
AddCommon stock$109.2K+2K
+2.61%
85,121
0.10% of shares
low
Q1 2026
as of
Schroder Investment Management Group
13F manager
AddCommon stock$95.8K+2K
+3.43%
63,684
0.07% of shares
low
Q1 2026
as of
Intech Investment Management LLC
13F manager
TrimCommon stock$-92.4K-2K
-10.02%
16,443
0.02% of shares
low
Q4 2025
as of
Persistent Asset Partners Ltd
13F manager
NewCommon stock$73.6K+2K
2,246
<0.01% of shares
low
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