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Spero Therapeutics, Inc.

Institutional holders · 13F as of Mar 31, 2026

58 holders

HolderValue ↓Shares% of shares
GSK PLC$21.51M9,190,60615.78%
PFIZER INC$5.50M2,362,3484.06%
VANGUARD GROUP INC$4.85M2,083,4623.58%
Renaissance Technologies LLC$2.78M1,189,2352.04%
TWO SIGMA INVESTMENTS, LP$2.07M885,6311.52%
Alphabet Inc.$1.97M889,9791.53%
Anson Funds Management LP$1.46M625,0621.07%
BlackRock, Inc.$1.31M594,4041.02%
GEODE CAPITAL MANAGEMENT, LLC$1.22M519,9220.89%
Citadel Advisors LLC$927.0K397,8640.68%
SUSQUEHANNA INTERNATIONAL GROUP, LLP$684.3K293,7000.50%
Informed Momentum Co LLC$508.1K218,0840.37%
TWO SIGMA ADVISERS, LP$504.7K216,6000.37%
STATE STREET CORPORATION$474.6K214,7510.37%
Ionic Capital Management LLC$458.5K195,9390.34%
INTREPID FAMILY OFFICE LLC$384.4K165,0000.28%
JANE STREET GROUP, LLC$368.9K158,3440.27%
MARSHALL WACE, LLP$367.5K157,0720.27%
SEI INVESTMENTS CO$307.6K132,0100.23%
NORTHERN TRUST CORP$281.9K120,9840.21%
Squarepoint Ops LLC$278.3K119,4340.21%
UBS Group AG$271.3K116,4470.20%
BRIDGEWAY CAPITAL MANAGEMENT, LLC$268.6K114,8000.20%
ADAR1 Capital Management, LLC$265.2K113,8390.20%
Shay Capital LLC$140.5K60,2890.10%
Point72 Asset Management, L.P.$101.5K43,5790.07%
OMERS Administration Corporation$92.2K39,4000.07%
Quadrature Capital Ltd$88.1K37,7990.06%
SIMPLEX TRADING, LLC$83.1K35,6860.06%
Capital Asset Advisory Services LLC$81.7K32,5480.06%
AXXCESS WEALTH MANAGEMENT, LLC$75.8K32,5480.06%
Three Seasons Wealth, LLC$69.9K30,0000.05%
Dimensional Fund Advisors LP$69.0K29,7680.05%
CHARLES SCHWAB INVESTMENT MANAGEMENT INC$66.6K28,5650.05%
Invesco Ltd.$57.6K24,7050.04%
Millennium Management LLC$56.2K24,1070.04%
Assenagon Asset Management S.A.$43.4K18,6360.03%
Torrey Growth & Income Advisors$39.7K17,0250.03%
XTX Topco Ltd$35.4K15,1750.03%
Texas Yale Capital Corp.$23.3K10,0000.02%
Tower Research Capital LLC (TRC)$16.8K7,2150.01%
JONES FINANCIAL COMPANIES LLLP$15.1K6,4770.01%
JPMORGAN CHASE & CO$12.5K5,3730.01%
CULLEN/FROST BANKERS, INC.$7.0K3,0000.01%
BANK OF AMERICA CORP /DE$1.7K7440.00%
Morgan Stanley$7293130.00%
OSAIC HOLDINGS, INC.$6752900.00%
GSA CAPITAL PARTNERS LLP$651278,3040.48%
Rockefeller Capital Management L.P.$4662000.00%
WELLS FARGO & COMPANY/MN$4662000.00%
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