Companies / SPYRE THERAPEUTICS, INC. / Institutional holders

Spyre Therapeutics, Inc.

Institutional holders · 13F as of Dec 31, 2025

Holder	Value ↓	Shares	% of shares
Barclays PLC	$5.98M	182,524	0.21%
Universal- Beteiligungs- und Servicegesellschaft mbH	$5.61M	171,211	0.19%
Nuveen, LLC	$4.95M	150,980	0.17%
Invesco Ltd.	$4.94M	150,934	0.17%
Patient Square Capital LP	$4.91M	150,000	0.17%
RHUMBLINE ADVISERS	$4.29M	85,121	0.10%
MANUFACTURERS LIFE INSURANCE COMPANY, THE	$4.14M	129,013	0.15%
Parkman Healthcare Partners LLC	$4.08M	124,485	0.14%
Atle Fund Management AB	$3.49M	62,735	0.07%
MERCER GLOBAL ADVISORS INC /ADV	$3.48M	106,316	0.12%
F/m Investments LLC	$3.40M	103,718	0.12%
CITIGROUP INC	$3.28M	100,058	0.11%
SEVEN GRAND MANAGERS, LLC	$3.28M	100,000	0.11%
B Group, Inc.	$3.28M	100,000	0.11%
ALPS Advisors, Inc.	$3.23M	63,939	0.07%
Swiss National Bank	$3.16M	96,500	0.11%
PRUDENTIAL FINANCIAL INC	$3.00M	59,555	0.07%
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	$2.99M	59,242	0.07%
SCHRODER INVESTMENT MANAGEMENT GROUP	$2.89M	63,684	0.07%
Rafferty Asset Management, LLC	$2.87M	56,920	0.06%
Balyasny Asset Management L.P.	$2.80M	55,477	0.06%
VOYA INVESTMENT MANAGEMENT LLC	$2.72M	53,970	0.06%
WELLS FARGO & COMPANY/MN	$2.70M	82,416	0.09%
Dimensional Fund Advisors LP	$2.53M	77,290	0.09%
AllianceBernstein L.P.	$2.32M	70,900	0.08%
Citadel Advisors LLC	$2.09M	63,904	0.07%
JPMORGAN CHASE & CO	$2.06M	62,951	0.07%
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	$2.04M	62,216	0.07%
Legal & General Group Plc	$1.85M	56,448	0.06%
Susquehanna Portfolio Strategies, LLC	$1.74M	53,101	0.06%
Arizona State Retirement System	$1.37M	15,471	0.02%
PROFUND ADVISORS LLC	$1.31M	26,043	0.03%
AMERIPRISE FINANCIAL INC	$1.25M	38,256	0.04%
MetLife Investment Management, LLC	$1.25M	38,011	0.04%
ExodusPoint Capital Management, LP	$1.24M	37,871	0.04%
Cinctive Capital Management LP	$1.18M	35,935	0.04%
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.	$1.15M	35,144	0.04%
ADAR1 Capital Management, LLC	$1.12M	34,051	0.04%
STEMPOINT CAPITAL LP	$1.06M	32,377	0.04%
AQR Capital Management, LLC	$1.05M	20,874	0.02%
BNP PARIBAS FINANCIAL MARKETS	$939.7K	18,630	0.02%
STATE OF WISCONSIN INVESTMENT BOARD	$892.8K	27,252	0.03%
Waverly Advisors, LLC	$850.3K	25,954	0.03%
Optimize Financial Inc	$829.8K	25,331	0.03%
INTECH INVESTMENT MANAGEMENT LLC	$829.4K	16,443	0.02%
VIRGINIA RETIREMENT SYSTEMS ET Al	$817.4K	24,950	0.03%
Persistent Asset Partners Ltd	$777.7K	8,760	0.01%
Assenagon Asset Management S.A.	$725.2K	22,136	0.03%
Zurcher Kantonalbank (Zurich Cantonalbank)	$703.9K	13,955	0.02%
ProShare Advisors LLC	$680.8K	13,498	0.02%