Prelude Therapeutics Incorporated

Institutional holders · 13F as of Mar 31, 2026

Holder	Value ↓	Shares	% of shares
ORBIMED ADVISORS LLC	$37.31M	10,909,256	13.67%
Baker Bros. Advisors LP	$34.62M	10,123,824	12.69%
BlackRock, Inc.	$9.58M	1,797,501	2.25%
VANGUARD GROUP INC	$4.10M	1,413,986	1.77%
TWO SIGMA INVESTMENTS, LP	$3.16M	923,626	1.16%
Kynam Capital Management, LP	$2.29M	788,867	0.99%
STATE STREET CORPORATION	$2.29M	428,787	0.54%
Boxer Capital Management, LLC	$1.62M	2,108,014	2.64%
Millennium Management LLC	$1.31M	382,737	0.48%
MARSHALL WACE, LLP	$1.23M	358,906	0.45%
GEODE CAPITAL MANAGEMENT, LLC	$1.03M	302,458	0.38%
Morgan Stanley	$971.3K	334,916	0.42%
Renaissance Technologies LLC	$941.2K	275,200	0.34%
TWO SIGMA ADVISERS, LP	$688.2K	237,300	0.30%
TD ASSET MANAGEMENT INC	$465.9K	160,652	0.20%
SUSQUEHANNA INTERNATIONAL GROUP, LLP	$394.1K	135,909	0.17%
Sphera Funds Management Ltd.	$356.0K	122,752	0.15%
THE GOLDMAN SACHS GROUP, INC.	$340.7K	117,477	0.15%
JANE STREET GROUP, LLC	$322.0K	111,040	0.14%
MANUFACTURERS LIFE INSURANCE COMPANY, THE	$200.4K	70,546	0.09%
BRIDGEWAY CAPITAL MANAGEMENT, LLC	$183.0K	53,500	0.07%
Point72 Asset Management, L.P.	$171.6K	59,168	0.07%
DEUTSCHE BANK AG	$148.3K	27,824	0.03%
XTX Topco Ltd	$145.5K	50,159	0.06%
NORTHERN TRUST CORP	$145.3K	50,120	0.06%
Focus Partners Wealth	$145.0K	50,007	0.06%
Connor, Clark & Lunn Investment Management Ltd.	$133.7K	46,090	0.06%
OMERS Administration Corporation	$111.8K	32,700	0.04%
Cerity Partners LLC	$95.6K	32,953	0.04%
Qube Research & Technologies Ltd	$62.5K	21,551	0.03%
PRUDENTIAL FINANCIAL INC	$59.6K	17,420	0.02%
HSBC HOLDINGS PLC	$39.5K	13,652	0.02%
Graham Capital Management, L.P.	$38.8K	11,343	0.01%
BANK OF AMERICA CORP /DE	$28.4K	9,808	0.01%
Barclays PLC	$24.9K	8,602	0.01%
FMR LLC	$17.8K	6,152	0.01%
Royal Bank of Canada	$8.0K	2,331	0.00%
SBI Securities Co., Ltd.	$7.9K	2,741	0.00%
The PNC Financial Services Group, Inc.	$6.2K	1,171	0.00%
CALDWELL SUTTER CAPITAL, INC.	$5.8K	2,000	0.00%
UBS Group AG	$5.4K	1,857	0.00%
NISA INVESTMENT ADVISORS, LLC	$4.7K	1,634	0.00%
T. Rowe Price Associates, Inc.	$2.2K	755,956	0.95%
ACADIAN ASSET MANAGEMENT LLC	$1.6K	535,703	0.67%
GROUP ONE TRADING LLC	$1.4K	500	0.00%
BNP PARIBAS FINANCIAL MARKETS	$325	95	0.00%
JPMORGAN CHASE & CO	$180	62	0.00%
Optiver Holding B.V.	$58	20	0.00%
IFP Advisors, Inc	$3	1	0.00%
CITIGROUP INC	$3	1	0.00%